Sirolimus (Subconjunctival) is a powerful immunomodulator medicine given as an injection under the conjunctiva of the eye, used in selected cases of non-infectious uveitis.
| Drug class | mTOR Inhibitor |
|---|---|
| Type | Single |
| Forms | Subconjunctival Injection |
| Common strength | Varies |
| Prescription status | Prescription (hospital use) |
What Sirolimus (Subconjunctival) is used for
Sirolimus (Subconjunctival) is a medicine that belongs to a category called immunomodulators. It is used in specific, investigational circumstances to treat:
- Non-infectious uveitis
Uveitis is an inflammation of the uvea, which is the middle layer of the eye. This layer contains many blood vessels that nourish the eye. When the uvea becomes inflamed, it can lead to pain, redness, blurred vision, and sensitivity to light. If left untreated, severe uveitis can cause serious complications, including glaucoma, cataracts, and even vision loss. Non-infectious uveitis means that the inflammation is not caused by bacteria, viruses, or other germs, but rather by an overactive immune response within the body. Sirolimus (Subconjunctival) helps to manage this immune response locally within the eye.
How it works
Sirolimus (Subconjunctival) works by targeting a specific pathway in the body called mTOR (mammalian target of rapamycin). By inhibiting mTOR locally within the eye, this medicine helps to suppress the immune system’s overactivity that causes inflammation in non-infectious uveitis. This local action helps to reduce the inflammation directly in the eye, aiming to protect eye structures and preserve vision.
How it’s used
Sirolimus (Subconjunctival) is given as an injection directly under the conjunctiva of the eye. The conjunctiva is the clear membrane that covers the white part of your eye. This medicine is never for self-use and must always be administered by a specialist in a hospital or clinic setting. The specific strength and frequency of the injection will be determined by your ophthalmologist based on your individual condition and the treatment protocol. It is crucial to follow all instructions provided by your doctor and attend all scheduled follow-up appointments.
Always follow your ophthalmologist’s exact instructions.
Brands in India
Hospital-prepared or not marketed as a retail brand in India.
Please note
Powerful medicine that suppresses the immune system. Screening for tuberculosis and hepatitis is usually required before starting, and it raises the risk of infection. Used only under specialist supervision with regular monitoring. Not currently approved or routinely available in India — included for reference; ask your ophthalmologist about approved alternatives. This is given only by specialists in a hospital or clinic setting and is never for self-use.
Precautions & side effects
Sirolimus (Subconjunctival) is a powerful medicine that suppresses the immune system. Due to its nature and the fact that it is used in investigational or selected cases, there are important precautions to be aware of:
- Specialist Supervision: This medicine is only used under the strict supervision of an ophthalmology specialist.
- Screening: Before starting treatment, you will usually need to undergo screening for conditions like tuberculosis and hepatitis. This is because suppressing the immune system can potentially reactivate these latent infections.
- Increased Risk of Infection: Because it suppresses the immune system, Sirolimus (Subconjunctival) raises your risk of developing infections. Your doctor will monitor you closely for any signs of infection.
- Regular Monitoring: Regular monitoring by your specialist is essential throughout the treatment period to assess its effectiveness and manage any potential side effects.
- Not Routinely Available in India: Please note that Sirolimus (Subconjunctival) is not currently approved or routinely available in India for general use. It is included here for reference as an investigational treatment. Your ophthalmologist will discuss approved and available alternatives that are suitable for your condition.
- Hospital Use Only: This injection is given only by specialists in a hospital or clinic setting and is never for self-use.
Understanding Uveitis: The Condition Sirolimus (Subconjunctival) May Treat
Uveitis is an inflammation of the uvea, which is the middle layer of your eye. The uvea is vital because it contains many blood vessels that supply nutrients to the eye. When this layer becomes inflamed, it can lead to a range of uncomfortable symptoms such as eye pain, redness, blurred vision, and increased sensitivity to light. Depending on which part of the uvea is affected, uveitis can be classified as anterior (front of the eye), intermediate (middle of the eye), or posterior (back of the eye), or even panuveitis (affecting all parts). If left untreated, uveitis can lead to serious complications, including the development of cataracts (clouding of the eye’s natural lens), glaucoma (increased pressure inside the eye that can damage the optic nerve), and even permanent vision loss. Non-infectious uveitis, the type Sirolimus (Subconjunctival) may treat, means that the inflammation is not caused by germs like bacteria or viruses, but rather by an overactive immune response within your own body. Managing this immune response is key to controlling the inflammation and protecting your vision. Your ophthalmologist will conduct a thorough examination to determine the type and cause of your uveitis and recommend the most appropriate treatment plan for you.
General Advice for Eye Care and Hygiene
Maintaining good eye hygiene is crucial, especially when undergoing treatment for an eye condition. Always wash your hands thoroughly with soap and water before touching your eyes or administering any eye medication. Avoid rubbing your eyes, as this can introduce germs and worsen irritation or inflammation. If you wear contact lenses, your doctor will advise you whether you should continue wearing them during your treatment, as some eye conditions or medications may require you to temporarily stop. Always follow your doctor’s specific instructions regarding contact lens use. Store all eye medications as directed by your pharmacist or doctor, usually in a cool, dry place away from direct sunlight. Never use expired medication. If you are using other eye drops or ointments, ask your doctor about the correct order and timing for applying them to ensure each medicine works effectively. It is also important to protect your eyes from environmental irritants like dust, smoke, and strong winds, which can exacerbate eye conditions. Wearing sunglasses outdoors can help shield your eyes from bright light and wind.
When to Seek Medical Help
While undergoing treatment for uveitis, it is very important to be aware of when to seek immediate medical attention. Always follow your ophthalmologist’s advice regarding follow-up appointments and what symptoms to watch out for. You should contact your doctor or Pristine Eye Hospitals immediately if you experience any sudden worsening of your symptoms, such as increased eye pain, severe redness, a sudden decrease in vision, new floaters or flashes of light, or extreme sensitivity to light. Additionally, if you develop any signs of infection, such as fever, chills, or discharge from your eye, it is crucial to seek prompt medical advice, especially since Sirolimus (Subconjunctival) can increase the risk of infection. Do not hesitate to reach out to your healthcare provider if you have any concerns or questions about your treatment or if you experience any new or unusual symptoms. Regular communication with your medical team is vital for effective management of your eye condition and ensuring your safety and well-being.
Frequently asked questions
What is Sirolimus (Subconjunctival) used for?
Sirolimus (Subconjunctival) is an immunomodulator medicine used in selected, investigational cases to treat non-infectious uveitis, which is an inflammation of the middle layer of the eye not caused by germs.
How does Sirolimus (Subconjunctival) work?
Sirolimus (Subconjunctival) works by inhibiting a pathway called mTOR locally within the eye. This action helps to suppress the overactive immune response that causes inflammation in non-infectious uveitis.
What are the common Indian brands of Sirolimus (Subconjunctival)?
Sirolimus (Subconjunctival) is typically prepared by the hospital pharmacy for specific use and is not available under retail brand names in India. It is not currently approved or routinely available in India for general use.
How is Sirolimus (Subconjunctival) administered?
Sirolimus (Subconjunctival) is given as an injection directly under the conjunctiva of the eye. It is always administered by a specialist in a hospital or clinic setting and is never for self-use.
Is a prescription needed for Sirolimus (Subconjunctival)?
Yes, Sirolimus (Subconjunctival) is a powerful prescription-only medicine used exclusively in a hospital setting under specialist supervision.
What are the key precautions for Sirolimus (Subconjunctival)?
Key precautions include that it is a powerful immune-suppressing medicine, usually requiring screening for tuberculosis and hepatitis before starting. It raises the risk of infection and is used only under specialist supervision with regular monitoring. It is not routinely approved or available in India and is given only by specialists in a hospital or clinic, never for self-use.
References
- Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis: primary 6-month results of the SAVE Study – PMC
- Eye health – MedlinePlus (US National Library of Medicine)
- Eye health information – American Academy of Ophthalmology
- Learn about eye health – National Eye Institute (NIH)
- Blindness and vision impairment – World Health Organization
Medically reviewed by Dr. C Jagadesh Reddy, Chief Surgeon: Cornea, Cataract and Refractive Surgery — last reviewed 2026-07-28.
This page is for general education only and is not a substitute for professional medical advice, diagnosis or treatment. Never self-medicate or reuse an old prescription. Always consult a qualified ophthalmologist before starting, changing or stopping any eye medicine.