Golimumab is a powerful immunomodulator medicine, administered as a subcutaneous injection, used to treat specific types of severe eye inflammation (uveitis) that haven't responded to other treatments or are linked to spondyloarthritis.
| Drug class | Biologic (Anti-TNF) |
|---|---|
| Type | Single |
| Forms | Subcutaneous Injection |
| Common strength | 50 mg |
| Common Indian brands | Simponi |
| Prescription status | Prescription |
What Golimumab is used for
Golimumab is a specialised medicine prescribed by ophthalmologists at Pristine Eye Hospitals for certain serious inflammatory conditions affecting the eye. It is particularly used when other treatments haven’t been effective or when the eye condition is associated with a specific type of arthritis.
- Refractory non-infectious uveitis: This refers to severe inflammation inside the eye (uveitis) that is not caused by an infection and has not responded well to standard treatments.
- Spondyloarthritis-associated uveitis: This is inflammation of the eye (uveitis) that occurs in patients who also have spondyloarthritis, a group of inflammatory diseases primarily affecting the spine and joints.
By treating these conditions, Golimumab aims to reduce inflammation, protect your vision, and improve your overall eye health.
How it works
Golimumab belongs to a category of medicines called biologics, which are designed to target specific parts of the immune system. Specifically, Golimumab works by blocking a protein in your body called TNF-alpha (Tumour Necrosis Factor-alpha).
TNF-alpha is a natural substance produced by your immune system. While it plays a role in fighting infections, too much TNF-alpha can lead to chronic inflammation in various parts of the body, including the eyes. By blocking TNF-alpha, Golimumab helps to reduce the excessive inflammation that causes conditions like refractory non-infectious uveitis and spondyloarthritis-associated uveitis. This action helps to calm the immune response, reduce swelling and pain in the eye, and prevent further damage.
How it’s used
Golimumab is administered as a subcutaneous injection, which means it is given just under the skin. This medicine is typically given once a month.
The standard dose for adults is 50 mg, given once every month. Your doctor or a trained healthcare professional will show you how to administer the injection correctly, or it may be given to you at the hospital or clinic. It is crucial to follow their instructions precisely regarding the injection technique, site rotation, and disposal of used needles.
It is very important to stick to your prescribed dosing schedule. If you miss a dose, please contact your doctor at Pristine Eye Hospitals immediately for advice on what to do. Do not take a double dose to make up for a missed one.
Remember, this is a powerful medicine, and its use requires careful guidance from your ophthalmologist. They will monitor your progress and ensure the treatment is working effectively and safely for you.
Always follow your ophthalmologist’s exact instructions.
Brands available in India
- Simponi
Brand availability and pricing vary; confirm with your pharmacist.
Please note
Powerful medicine that suppresses the immune system. Screening for tuberculosis and hepatitis is usually required before starting, and it raises the risk of infection. Used only under specialist supervision with regular monitoring.
Precautions & side effects
Golimumab is a powerful medicine that suppresses the immune system, and therefore, certain important precautions must be taken to ensure your safety and the effectiveness of the treatment. Your doctor at Pristine Eye Hospitals will discuss all these points with you in detail.
- Mandatory Screening: Before you start treatment with Golimumab, it is absolutely essential to undergo screening tests for certain infections, particularly tuberculosis (TB) and hepatitis. This is because suppressing the immune system can reactivate dormant infections.
- Increased Risk of Infection: Because Golimumab works by suppressing your immune system, it raises your risk of developing infections. It is crucial to be vigilant for any signs of infection, such as fever, chills, persistent cough, unexplained weight loss, or any unusual symptoms, and report them to your doctor immediately.
- Specialist Supervision and Monitoring: This medicine is only used under the close supervision of a specialist doctor, such as an ophthalmologist at Pristine Eye Hospitals, who has experience with immunomodulatory treatments. You will require regular monitoring throughout your treatment to check for effectiveness, side effects, and any potential complications.
- Prescription Only: Golimumab is a prescription-only medicine. You cannot obtain it without a valid prescription from your doctor.
- Discuss Your Medical History: Always inform your doctor about your complete medical history, including any past or current infections, other medical conditions (like heart failure, cancer), and all medicines you are currently taking, including over-the-counter drugs, supplements, and herbal remedies.
- Vaccinations: Discuss your vaccination history with your doctor. Live vaccines are generally not recommended while on Golimumab.
- Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, please inform your doctor. They will discuss the potential risks and benefits with you.
- Allergic Reactions: Although rare, some people may experience an allergic reaction to Golimumab. Seek immediate medical attention if you experience symptoms like rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.
Your healthcare team at Pristine Eye Hospitals is here to support you and ensure your treatment journey is as safe and effective as possible. Do not hesitate to ask any questions or voice any concerns you may have.
Understanding Uveitis: The Condition Golimumab Treats
Uveitis is a general term for inflammation of the uvea, the middle layer of the eye. The uvea consists of the iris (the coloured part of your eye), the ciliary body (which produces fluid inside the eye), and the choroid (a layer of blood vessels that nourishes the retina). When this part of the eye becomes inflamed, it can lead to a range of symptoms and, if left untreated, can potentially cause serious vision problems or even permanent vision loss.
Symptoms of uveitis can vary depending on which part of the uvea is affected and how severe the inflammation is. Common symptoms include eye pain, redness, sensitivity to light (photophobia), blurred vision, and seeing ‘floaters’ (small spots or lines that seem to drift across your vision). Sometimes, there might be no pain, and the only symptom is blurred vision. It’s crucial to seek prompt medical attention if you experience any of these symptoms, as early diagnosis and treatment can significantly improve the outcome.
Uveitis can be caused by various factors, including infections, injuries, or autoimmune diseases where the body’s immune system mistakenly attacks its own tissues. In some cases, like spondyloarthritis-associated uveitis, it’s linked to inflammatory conditions affecting other parts of the body. When uveitis is ‘non-infectious,’ it means it’s not caused by bacteria, viruses, or fungi, but rather by an overactive immune response. ‘Refractory’ means that the condition has been difficult to treat with standard therapies. Golimumab is specifically used for these more challenging types of uveitis, aiming to control the inflammation and protect your precious eyesight.
General Advice for Managing Your Eye Health During Treatment
While taking Golimumab, it’s important to maintain good overall health practices, especially since this medicine affects your immune system. Here are some general tips:
- Follow Your Doctor’s Appointments: Regular follow-up appointments with your ophthalmologist at Pristine Eye Hospitals are vital. These appointments allow your doctor to monitor your eye condition, assess the effectiveness of Golimumab, and check for any potential side effects. Do not miss these appointments.
- Report New Symptoms Promptly: Be vigilant for any new or worsening symptoms, not just related to your eyes but also general health. As Golimumab can increase the risk of infections, report any signs of infection (like fever, chills, persistent cough, unusual fatigue, or skin changes) to your doctor immediately.
- Maintain Good Hygiene: Practicing good hygiene can help reduce your risk of infections. This includes frequent hand washing, especially before and after touching your eyes or administering any eye drops/ointments (if prescribed alongside Golimumab). Avoid touching or rubbing your eyes unnecessarily.
- Protect Your Eyes: Wear sunglasses outdoors to protect your eyes from bright light, especially if you experience light sensitivity. If you wear contact lenses, discuss this with your doctor, as they might advise against wearing them during active inflammation or certain phases of treatment.
- Healthy Lifestyle: A balanced diet, adequate sleep, and regular, moderate exercise (as advised by your doctor) can support your overall well-being and immune system. Avoid smoking, as it can worsen many eye conditions.
- Inform Other Healthcare Providers: Always inform any other doctors, dentists, or healthcare professionals you see that you are taking Golimumab. This is crucial, especially before any surgeries or dental procedures, as it affects your immune system.
Remember, your healthcare team at Pristine Eye Hospitals is your partner in managing your eye health. Do not hesitate to ask questions or express any concerns you may have about your treatment or condition.
Frequently asked questions
What is Golimumab used for?
Golimumab is used to treat specific types of severe eye inflammation, known as refractory non-infectious uveitis (uveitis that hasn't responded to other treatments and isn't caused by infection) and spondyloarthritis-associated uveitis (uveitis linked to a type of arthritis).
How does Golimumab work?
Golimumab works by blocking a protein called TNF-alpha in your body. By blocking TNF-alpha, it helps to reduce the excessive inflammation that causes conditions like refractory non-infectious uveitis and spondyloarthritis-associated uveitis.
What are the common Indian brands for Golimumab?
In India, Golimumab is available under the brand name Simponi.
How is Golimumab typically used or administered?
Golimumab is administered as a 50 mg subcutaneous injection (under the skin) once a month. Your doctor or a healthcare professional will guide you on the correct administration.
Do I need a prescription for Golimumab?
Yes, Golimumab is a powerful medicine and requires a valid prescription from a specialist doctor.
What are the key precautions I should be aware of when taking Golimumab?
Before starting Golimumab, you will need mandatory screening for tuberculosis and hepatitis. This medicine suppresses your immune system, which raises your risk of infection. It must only be used under specialist supervision with regular monitoring, and you should report any signs of infection to your doctor immediately.
References
- Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience – PMC
- Golimumab – StatPearls – NCBI Bookshelf – NIH
- Eye health – MedlinePlus (US National Library of Medicine)
- Eye health information – American Academy of Ophthalmology
- Learn about eye health – National Eye Institute (NIH)
Medically reviewed by Dr. C Jagadesh Reddy, Chief Surgeon: Cornea, Cataract and Refractive Surgery — last reviewed 2026-07-28.
This page is for general education only and is not a substitute for professional medical advice, diagnosis or treatment. Never self-medicate or reuse an old prescription. Always consult a qualified ophthalmologist before starting, changing or stopping any eye medicine.