Amphotericin B / Voriconazole (intravitreal) is an antifungal medicine injected directly into the eye to treat serious fungal infections inside the eye.
| Drug class | Intravitreal Antifungal |
|---|---|
| Type | Single |
| Forms | Intravitreal Injection |
| Common strength | Amphotericin B 5-10 mcg; Voriconazole 100 mcg |
| Common Indian brands | Prepared in hospital pharmacy |
| Prescription status | Prescription (hospital use) |
What Amphotericin B / Voriconazole (intravitreal) is used for
Amphotericin B / Voriconazole (intravitreal) is a powerful medicine used to treat a very serious eye condition called fungal endophthalmitis. This is an infection inside your eye caused by fungi.
- Fungal endophthalmitis
How it works
This medicine works by delivering antifungal agents directly into the vitreous cavity, which is the jelly-like substance that fills the inside of your eye. By injecting the medicine directly into the eye, it can reach the site of the fungal infection effectively and help to eliminate the fungi causing the problem.
How it’s used
Amphotericin B / Voriconazole (intravitreal) is given as an injection directly into your eye by a retina specialist at the hospital. It is typically a single injection, but your doctor may decide to repeat it if needed, based on how your eye is responding to the treatment. This medicine is part of a comprehensive treatment plan and is often given along with other antifungal medicines that you might take by mouth or intravenously (into a vein), and sometimes even vitrectomy surgery (a surgical procedure to remove the infected vitreous gel from the eye).
Always follow your ophthalmologist’s exact instructions.
Brands available in India
- Prepared in hospital pharmacy
Brand availability and pricing vary; confirm with your pharmacist.
Please note
Given as an injection inside the eye by a retina specialist. After any intravitreal injection, seek help IMMEDIATELY if you develop increasing pain, redness, sensitivity to light or a drop in vision — these can be signs of a serious infection (endophthalmitis).
Precautions & side effects
It is very important to understand that Amphotericin B / Voriconazole (intravitreal) is a high-warn level medicine. It is always given as an injection inside the eye by a retina specialist. This treatment is part of a broader approach that often includes systemic antifungals (medicines taken orally or intravenously) and, in many cases, vitrectomy surgery.
Important Warning: After receiving any intravitreal injection (an injection inside the eye), it is crucial to seek medical help IMMEDIATELY if you experience any of the following symptoms:
- Increasing pain in your eye
- Increasing redness of your eye
- Increased sensitivity to light (photophobia)
- A noticeable drop in your vision
These symptoms can be signs of a serious infection called endophthalmitis, which requires urgent medical attention to prevent severe vision loss. Always follow your doctor’s instructions and attend all follow-up appointments.
Understanding Fungal Endophthalmitis
Fungal endophthalmitis is a serious infection inside your eye caused by fungi. This condition can lead to significant vision loss if not treated promptly and effectively. The eye has a jelly-like substance called the vitreous, and when fungi enter this area, they can multiply and cause inflammation and damage. This type of infection can sometimes occur after eye surgery, an eye injury, or if you have a weakened immune system. Symptoms can include blurred vision, pain, redness, sensitivity to light, and sometimes pus or discharge in the eye. Because it is such a serious condition, doctors at Pristine Eye Hospitals take a comprehensive approach to treatment, which often includes direct injections of antifungal medicines into the eye, along with other treatments.
At Pristine Eye Hospitals, our retina specialists are highly experienced in diagnosing and treating complex eye infections like fungal endophthalmitis. We use advanced diagnostic tools to identify the specific type of fungus causing the infection, which helps us tailor the most effective treatment plan for you. Our goal is to preserve your vision and ensure the best possible outcome. We understand that hearing you have a serious eye infection can be worrying, but please be assured that you are in expert hands. We will explain every step of your treatment and support you throughout your recovery journey.
Receiving an Intravitreal Injection
An intravitreal injection means that the medicine is injected directly into the vitreous cavity of your eye. This method is chosen for certain conditions, like fungal endophthalmitis, because it allows the medicine to reach the site of infection directly and in high concentrations, which is crucial for fighting serious infections. The procedure is performed by a retina specialist in a sterile environment, usually in a dedicated treatment room or operation theatre, to minimize the risk of complications. Before the injection, your eye will be numbed with anaesthetic eye drops to ensure you are comfortable. The doctor will also clean the area around your eye to prevent infection. You might feel a slight pressure during the injection, but it is generally not painful. After the injection, your doctor will give you specific instructions on what to expect and how to care for your eye.
It is normal to experience some mild discomfort, redness, or a feeling of something in your eye for a day or two after the injection. You might also see small floaters or specks in your vision, which usually settle down. However, it is extremely important to monitor your eye closely for any signs of complications. As mentioned in the precautions, if you notice increasing pain, redness, sensitivity to light, or a drop in your vision, you must contact Pristine Eye Hospitals immediately. These could be signs of a serious infection, and prompt treatment is essential. Always attend your follow-up appointments as scheduled, as these are vital for your doctor to monitor your progress and ensure the infection is clearing effectively. Do not rub your eye vigorously after the injection, and follow all hygiene instructions provided by our medical team.
General Eye Care and Hygiene
Maintaining good eye hygiene is always important, especially when you are undergoing treatment for an eye condition. Always wash your hands thoroughly with soap and water before touching your eyes or applying any eye drops or ointments. Avoid rubbing your eyes, especially after an injection, as this can introduce germs or irritate the treated eye. If you wear contact lenses, your doctor will advise you on when it is safe to resume wearing them, which is usually not immediately after an intravitreal injection. It is also a good practice to use clean towels and avoid sharing eye makeup or other personal items that come into contact with your eyes.
Store any prescribed eye drops or medicines as instructed by your pharmacist or doctor, typically in a cool, dry place away from direct sunlight. Do not use any eye drops or medicines that have expired. If you have any questions about your eye care, hygiene, or medication, please do not hesitate to ask your doctor or the nursing staff at Pristine Eye Hospitals. We are here to help you understand your treatment and ensure your recovery is as smooth and safe as possible. Remember, your active participation in your eye care, by following instructions and reporting any concerns promptly, plays a crucial role in achieving the best outcome for your vision.
Frequently asked questions
What is Amphotericin B / Voriconazole (intravitreal) used for?
Amphotericin B / Voriconazole (intravitreal) is used to treat a serious eye infection called fungal endophthalmitis, which is an infection inside your eye caused by fungi.
How does Amphotericin B / Voriconazole (intravitreal) work?
This medicine works by delivering antifungal agents directly into the vitreous cavity, the jelly-like substance inside your eye. This direct delivery helps to effectively fight and eliminate the fungal infection.
What are the common Indian brands for Amphotericin B / Voriconazole (intravitreal)?
Amphotericin B / Voriconazole (intravitreal) is not available under specific brand names from pharmacies. It is prepared in the hospital pharmacy specifically for your treatment.
How is Amphotericin B / Voriconazole (intravitreal) administered?
It is given as an injection directly into your eye by a retina specialist at the hospital. It is typically a single injection, but may be repeated if your doctor deems it necessary. It is often part of a broader treatment plan that includes other antifungal medicines and sometimes surgery.
Do I need a prescription for Amphotericin B / Voriconazole (intravitreal)?
Yes, Amphotericin B / Voriconazole (intravitreal) is a prescription medicine and is only used in a hospital setting under the direct supervision of a retina specialist.
What precautions should I take after receiving Amphotericin B / Voriconazole (intravitreal)?
After the injection, it is crucial to seek medical help IMMEDIATELY if you experience increasing pain, redness, sensitivity to light, or a drop in vision. These can be signs of a serious infection (endophthalmitis) and require urgent attention. Always follow your doctor's instructions and attend all follow-up appointments.
References
- Fungal Endophthalmitis – StatPearls – NCBI Bookshelf – NIH
- Endogenous Endophthalmitis: Diagnosis and Treatment – American Academy of Ophthalmology
- The Diagnosis and Treatment of Fungal Endophthalmitis: An Update – PMC – NIH
- Diabetic Retinopathy – National Eye Institute
- Eye health – MedlinePlus (US National Library of Medicine)
Medically reviewed by Dr. C Jagadesh Reddy, Chief Surgeon: Cornea, Cataract and Refractive Surgery — last reviewed 2026-07-28.
This page is for general education only and is not a substitute for professional medical advice, diagnosis or treatment. Never self-medicate or reuse an old prescription. Always consult a qualified ophthalmologist before starting, changing or stopping any eye medicine.